Rai Bhavana, Bansal Anshuma, Patel Firuza Darius, Sharma Suresh Chander
Department of Radiotherapy and Oncology and Regional Cancer Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India E-mail :
Asian Pac J Cancer Prev. 2014;15(12):4759-63. doi: 10.7314/apjcp.2014.15.12.4759.
Radiation therapy in ovarian cancers has been considered an outdated concept for many years, mainly due to toxicity and failure to show benefit in terms of survival. Chemotherapy has been extensively used after surgery for these cancers and it has almost replaced radiation therapy as an adjuvant treatment. Nevertheless, failures in ovarian cancers continue to occur even with the use of newer and effective chemotherapy regimens. About 70% patients demonstrate recurrence in the abdomen or pelvis after first line chemotherapy in ovarian cancers. With advances in technology and sophistication of radiation techniques, along with the molecular and biological knowledge of distinct histological subtypes, there is a need to redefine the role of radiation therapy. This review article focuses on the literature on use of radiation in ovarian cancers and its rationale and indications in the present day. For this, a literature pub med/medline search was performed from January 1975 to March 2014 to redefine the role of radiotherapy in ovarian cancers.
多年来，放射治疗在卵巢癌治疗中一直被视为过时的概念，主要是因为其毒性以及未能在生存方面显示出益处。化疗在这些癌症手术后被广泛应用，并且几乎已取代放射治疗成为辅助治疗手段。然而，即便使用更新且有效的化疗方案，卵巢癌仍会出现复发情况。约70%的卵巢癌患者在一线化疗后会出现腹部或盆腔复发。随着技术进步和放射技术的精细化，以及对不同组织学亚型分子和生物学认识的深入，有必要重新界定放射治疗的作用。这篇综述文章聚焦于卵巢癌放射治疗的相关文献及其当今的理论依据和适应证。为此，我们在1975年1月至2014年3月期间进行了PubMed/Medline文献检索，以重新界定放射治疗在卵巢癌中的作用。
