Immunochemistry Laboratory, Butantan Institute, São Paulo, Brazil.
Institute of Molecular and Experimental Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Mol Immunol. 2014 Oct;61(2):153-62. doi: 10.1016/j.molimm.2014.06.020. Epub 2014 Jul 3.
Nature is a wealthy source of agents that have been shown to be beneficial to human health, but nature is also a rich source of potential dangerous health damaging compounds. This review will summarise and discuss the agents from the animal kingdom that have been shown to interact with the human complement (C) system. Most of these agents are toxins found in animal venoms and animal secretions. In addition to the mechanism of action of these toxins, their contribution to the field of complement, their role in human pathology and the potential benefit to the venomous animal itself will be discussed. Potential therapeutic applications will also be discussed.
自然界是丰富的药物来源，已证实其中许多物质对人类健康有益，但自然界也是具有潜在危险的化合物的丰富来源，可能会损害人类健康。本综述将总结和讨论已证实可与人类补体（C）系统相互作用的动物王国中的物质。这些物质大多是在动物毒液和分泌物中发现的毒素。除了这些毒素的作用机制外，还将讨论它们对补体领域的贡献、在人类病理学中的作用以及对毒液动物自身的潜在益处。还将讨论潜在的治疗应用。
