人类血液中记忆性滤泡辅助性T细胞的表型与功能
Phenotype and functions of memory Tfh cells in human blood.
作者信息
Schmitt Nathalie, Bentebibel Salah-Eddine, Ueno Hideki
机构信息
Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX, 75204, USA.
Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak, Dallas, TX, 75204, USA; Institute of Biomedical Studies, Baylor University, Waco, TX, 76798, USA.
出版信息
Trends Immunol. 2014 Sep;35(9):436-42. doi: 10.1016/j.it.2014.06.002. Epub 2014 Jul 3.
Abstract
Our understanding of the origin and functions of human blood CXCR5(+) CD4(+) T cells found in human blood has changed dramatically in the past years. These cells are currently considered to represent a circulating memory compartment of T follicular helper (Tfh) lineage cells. Recent studies have shown that blood memory Tfh cells are composed of phenotypically and functionally distinct subsets. Here, we review the current understanding of human blood memory Tfh cells and the subsets within this compartment. We present a strategy to define these subsets based on cell surface profiles. Finally, we discuss how increased understanding of the biology of blood memory Tfh cells may contribute insight into the pathogenesis of autoimmune diseases and the mode of action of vaccines.
摘要
在过去几年里，我们对人类血液中CXCR5(+) CD4(+) T细胞的起源和功能的理解发生了巨大变化。目前认为这些细胞代表了T滤泡辅助（Tfh）谱系细胞的循环记忆区室。最近的研究表明，血液记忆Tfh细胞由表型和功能不同的亚群组成。在这里，我们综述了目前对人类血液记忆Tfh细胞及其在这个区室内的亚群的理解。我们提出了一种基于细胞表面特征来定义这些亚群的策略。最后，我们讨论了对血液记忆Tfh细胞生物学的深入理解如何有助于深入了解自身免疫性疾病的发病机制和疫苗的作用方式。
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