Baylor Institute for Immunology Research, Baylor Research Institute, Dallas, TX 75204, USA.
Immunity. 2013 Apr 18;38(4):831-44. doi: 10.1016/j.immuni.2012.12.008.
Systems immunology approaches were employed to investigate innate and adaptive immune responses to influenza and pneumococcal vaccines. These two non-live vaccines show different magnitudes of transcriptional responses at different time points after vaccination. Software solutions were developed to explore correlates of vaccine efficacy measured as antibody titers at day 28. These enabled a further dissection of transcriptional responses. Thus, the innate response, measured within hours in the peripheral blood, was dominated by an interferon transcriptional signature after influenza vaccination and by an inflammation signature after pneumococcal vaccination. Day 7 plasmablast responses induced by both vaccines was more pronounced after pneumococcal vaccination. Together, these results suggest that comparing global immune responses elicited by different vaccines will be critical to our understanding of the immune mechanisms underpinning successful vaccination.
系统免疫学方法被用于研究流感和肺炎球菌疫苗引起的固有和适应性免疫反应。这两种非活疫苗在接种后不同时间点显示出不同程度的转录反应。开发了软件解决方案来探索以 28 天抗体滴度衡量的疫苗效力的相关性。这些解决方案能够进一步剖析转录反应。因此，在接种流感疫苗后几小时内测量的固有反应主要是由干扰素转录特征主导，而在接种肺炎球菌疫苗后则主要是炎症特征。两种疫苗诱导的第 7 天浆母细胞反应在肺炎球菌疫苗接种后更为明显。这些结果表明，比较不同疫苗引起的全身免疫反应对于理解成功接种疫苗的免疫机制至关重要。
