Makanda A, Stijns-Cailteux M, Malengreau M, Vliers A
Service de cardiologie pédiatrique, Clinique universitaire Saint-Luc, Bruxelles.
Arch Mal Coeur Vaiss. 1989 May;82(5):791-4.
The diameter of the aortic root was measured in 151 patients with small ventricular septal defect (Qp/Qs less than 2 and pulmonary vascular resistance less than 1.5 U.m-2) and correlated with the presence of absence of aortic regurgitation. In 26 cases the aortic juxtavalvular region (bulbus) was dilated above 2 SD compared to a control group. All patients with aortic regurgitation of with cusp prolapse belonged to this group of 26 cases. Aortic root dilatation seems to have a specificity of 89 p. 100, a sensitivity of 75 p. 100 and a negative predictive value of 98 p. 100 in relation to the occurrence of aortic insufficiency. The finding of an aortic root dilatation associated with a ventricular septal defect should incite to a closer supervision of non-operated patients should be used as an argument when discussing the surgical closure of the ventricular septal defect.
对151例小型室间隔缺损（肺循环血流量与体循环血流量之比小于2且肺血管阻力小于1.5U.m-2）患者测量主动脉根部直径，并将其与有无主动脉反流进行关联分析。与对照组相比，26例患者的主动脉瓣旁区域（主动脉球）扩张超过2个标准差。所有伴有主动脉反流或瓣叶脱垂的患者均属于这26例患者。就主动脉瓣关闭不全的发生而言，主动脉根部扩张似乎具有89%的特异性、75%的敏感性和98%的阴性预测值。发现与室间隔缺损相关的主动脉根部扩张，应促使对未手术患者进行更密切的监测，在讨论室间隔缺损的手术闭合时应将其作为一个依据。
