Lee Kyoung Min, Kwon Soon-Sun, Chung Chin Youb, Lee Seung Yeol, Kim Tae Gyun, Choi Young, Park Moon Seok
Department of Orthopaedic Surgery, Seoul National University Bundang Hospital, 300 Gumi-Dong, Bundang-Gu, Sungnam, Kyungki, 463-707, South Korea.
J Bone Miner Metab. 2015 Jul;33(4):401-9. doi: 10.1007/s00774-014-0600-z. Epub 2014 Jul 8.
The aim of this study was to investigate the gender- and body-site-specific factors associated with bone mineral density (BMD) at the femoral neck and lumbar spine in a non-institutionalized population aged ≥50 years characterized by low average calcium intake. The comprehensive data utilized were from the 2010 Fifth Korea National Health and Nutrition Examination Survey, which included health behavior questionnaire, blood and urine tests, dual-energy X-ray absorptiometry, and nutrition intake. The factors associated with BMD at the femoral neck and lumbar spine in both genders were analyzed separately using multiple regression analysis with a stepwise selection. The average daily calcium intake in the male subjects was 565.8 mg and in the female subjects was 443.7 mg. In multiple regression analysis, age, body mass index (BMI), alkaline phosphatase (ALP), lead, daily calcium intake, and cadmium were the significant factors associated with femoral neck BMD in male subjects. BMI, creatinine (Cr), total body fat percentile, lead, ALP, and hypertension were found to be the significant factors associated with lumbar spine BMD in male subjects. In the female subjects, the significant factors associated with femoral neck BMD were age, BMI, ALP, house income, and total body fat percentile, while menopause, Cr, mercury, house income, BMI, and ALP were found to be the significant factors associated with lumbar spine BMD. In conclusion, different factors were associated with BMD depending on gender and the body site tested (femoral neck or lumbar spine). These gender- and body-site-specific factors need to be considered for the prevention and management of osteoporosis.
本研究的目的是调查在平均钙摄入量较低的≥50岁非机构化人群中，与股骨颈和腰椎骨密度（BMD）相关的性别和身体部位特异性因素。所使用的综合数据来自2010年第五次韩国全国健康与营养检查调查，其中包括健康行为问卷、血液和尿液检测、双能X线吸收法以及营养摄入量。使用逐步选择的多元回归分析分别分析了与男女股骨颈和腰椎骨密度相关的因素。男性受试者的平均每日钙摄入量为565.8毫克，女性受试者为443.7毫克。在多元回归分析中，年龄、体重指数（BMI）、碱性磷酸酶（ALP）、铅、每日钙摄入量和镉是与男性受试者股骨颈骨密度相关的显著因素。发现BMI、肌酐（Cr）、全身脂肪百分比、铅、ALP和高血压是与男性受试者腰椎骨密度相关的显著因素。在女性受试者中，与股骨颈骨密度相关的显著因素是年龄、BMI、ALP、家庭收入和全身脂肪百分比，而绝经、Cr、汞、家庭收入、BMI和ALP被发现是与腰椎骨密度相关的显著因素。总之，根据性别和所检测的身体部位（股骨颈或腰椎），不同的因素与骨密度相关。在骨质疏松症的预防和管理中需要考虑这些性别和身体部位特异性因素。
