Zhang Jie, Xie Ying, Su Hang, Tao Jingyan, Sun Yeming, Li Liren, Liang Haiyan, He Ruqian, Han Bin, Lu Yuling, Sun Haiwei, Wei Youdan, Guo Jun, Zhang Xiang Yang, He Jincai
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China; Department of Neurology, Taizhou Municipal Hospital, Taizhou 317700, China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China.
Drug Alcohol Depend. 2014 Sep 1;142:191-6. doi: 10.1016/j.drugalcdep.2014.06.021. Epub 2014 Jun 23.
Depression, a common comorbidity of drug abuse, is often a core component of withdrawal symptoms; however, risk factors associated with depressive symptoms during the acute stage of withdrawal among methamphetamine (METH) users are not well understood. This study investigated the correlations between several potential risk factors and depressive symptoms during acute METH withdrawal in a Han Chinese population.
A total of 243 eligible Chinese METH users were recruited from Wenzhou Sanyang Detoxification Institute in Zhejiang province from November 2012 to June 2013. A set of self-administrative questionnaires were used to collect information about socio-demographics, drug use history and depression. Thirteen-item Beck Depression Inventory (BDI-13) was used to measure depressive symptoms.
METH users had a mean BDI-13 score of 12.39; 157 subjects (64.6%) reported depressive symptoms during METH withdrawal, of which 74 subjects (30.5%) reported moderate depressive symptoms and 83 subjects (34.1%) reported severe depressive symptoms. Higher frequency of drug use and history of METH-use relapse were associated with depressive symptoms (adjusted OR=2.8; 95% CI=1.56-5.04) and (adjusted OR=3.4; 95% CI=1.36-8.49), respectively. Moderate alcohol drinking was associated with less risk for depressive symptoms during acute withdrawal (adjusted OR=0.54; 95% CI=0.31-0.93).
Depressive symptoms are common during early METH withdrawal. In addition, several risk factors including frequency of METH use and history of relapse were positively associated with depressive symptoms during that period while moderate alcohol drinking was negatively associated with depressive symptoms.
抑郁症是药物滥用常见的共病，通常是戒断症状的核心组成部分；然而，甲基苯丙胺（METH）使用者在急性戒断阶段与抑郁症状相关的风险因素尚未完全明确。本研究调查了汉族人群急性METH戒断期间几种潜在风险因素与抑郁症状之间的相关性。
2012年11月至2013年6月，从浙江省温州三阳戒毒所招募了243名符合条件的中国METH使用者。使用一套自填式问卷收集社会人口统计学、吸毒史和抑郁症相关信息。采用13项贝克抑郁量表（BDI-13）测量抑郁症状。
METH使用者的BDI-13平均得分为12.39；157名受试者（64.6%）在METH戒断期间报告有抑郁症状，其中74名受试者（30.5%）报告有中度抑郁症状，83名受试者（34.1%）报告有重度抑郁症状。吸毒频率较高和METH使用复发史分别与抑郁症状（调整后的OR=2.8；95%CI=1.56-5.04）和（调整后的OR=3.4；95%CI=1.36-8.49）相关。适度饮酒与急性戒断期间抑郁症状风险较低相关（调整后的OR=0.54；95%CI=0.31-0.93）。
抑郁症状在METH早期戒断期间很常见。此外，包括METH使用频率和复发史在内的几个风险因素与该时期的抑郁症状呈正相关，而适度饮酒与抑郁症状呈负相关。
