Zhang Jie, Su Hang, Tao Jingyan, Xie Ying, Sun Yeming, Li Liren, Zhang Xiang Yang, Hu Zhenyu, He Jincai
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China; Department of Neurology, Taizhou Municipal Hospital, Taizhou 317700, PR China.
Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, PR China.
Addict Behav. 2015 Apr;43:7-10. doi: 10.1016/j.addbeh.2014.10.032. Epub 2014 Nov 1.
High level of impulsivity as well as depression is thought to be involved in the maintenance and development of methamphetamine (METH) addiction. However, the relationship between impulsivity and depression has not been studied thoroughly in METH dependence subjects, especially in early METH abstinent subjects. In this study, our objective is to explore the interplay between the depressive symptoms and impulsivity in early METH abstinent subjects.
A total of 182 early abstinent METH dependent subjects (abstinence for 1-7 days) were recruited and the level of impulsivity was measured by the Barratt Impulsiveness Scale (BIS-11). Depressive symptoms and anxiety symptoms were assessed by the short 13-item Beck Depression Inventory (BDI-13) and Beck Anxiety Inventory (BAI) respectively.
Global impulsivity of BIS-11 was significantly correlated with depressive symptoms among early METH abstinent subjects (r=0.283, p=0.001). Moreover, all subscales of BIS-11 were also found to be correlated with depressive symptoms: correlation with attentional impulsivity (r=0.202, p=0.006); correlation with motor impulsivity (r=0.267, p=0.001); and correlation with non-planning impulsivity (r=0.177, p=0.017).
This study showed a relationship between impulsivity and depression, which may further the comprehension of motivational elements contributing to the maintenance and development of METH use disorder. Future research would be dedicated to exploring underlying mechanisms of association between impulsivity and depression.
人们认为，高冲动性以及抑郁与甲基苯丙胺（METH）成瘾的维持和发展有关。然而，在METH依赖者中，尤其是在早期METH戒断者中，冲动性与抑郁之间的关系尚未得到充分研究。在本研究中，我们的目的是探讨早期METH戒断者抑郁症状与冲动性之间的相互作用。
共招募了182名早期METH戒断依赖者（戒断1 - 7天），并通过巴拉特冲动性量表（BIS - 11）测量冲动性水平。分别采用13项简短版贝克抑郁量表（BDI - 13）和贝克焦虑量表（BAI）评估抑郁症状和焦虑症状。
在早期METH戒断者中，BIS - 11的总体冲动性与抑郁症状显著相关（r = 0.283，p = 0.001）。此外，还发现BIS - 11的所有子量表均与抑郁症状相关：与注意冲动性的相关性（r = 0.202，p = 0.006）；与运动冲动性的相关性（r = 0.267，p = 0.001）；以及与无计划冲动性的相关性（r = 0.177，p = 0.017）。
本研究表明冲动性与抑郁之间存在关联，这可能有助于进一步理解导致METH使用障碍维持和发展的动机因素。未来的研究将致力于探索冲动性与抑郁之间关联的潜在机制。
