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在视泡的近远轴模式形成过程中，Cdon作为一种刺猬信号（Hedgehog）诱饵受体发挥作用。

Cdon acts as a Hedgehog decoy receptor during proximal-distal patterning of the optic vesicle.

作者信息

Cardozo Marcos Julián, Sánchez-Arrones Luisa, Sandonis Africa, Sánchez-Camacho Cristina, Gestri Gaia, Wilson Stephen W, Guerrero Isabel, Bovolenta Paola

机构信息

1] Centro de Biología Molecular Severo Ochoa, Consejo Superior de Investigaciones Científicas-Universidad Autónoma de Madrid, 28049 Madrid Spain [2] Ciber de Enfermedades Raras (CIBERER), ISCIII, c/ Nicolas Cabrera 1, 28049 Madrid Spain.

1] Ciber de Enfermedades Raras (CIBERER), ISCIII, c/ Nicolas Cabrera 1, 28049 Madrid Spain [2].

出版信息

Nat Commun. 2014 Jul 8;5:4272. doi: 10.1038/ncomms5272.

DOI:10.1038/ncomms5272
PMID:25001599
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4102123/
Abstract

Patterning of the vertebrate optic vesicle into proximal/optic stalk and distal/neural retina involves midline-derived Hedgehog (Hh) signalling, which promotes stalk specification. In the absence of Hh signalling, the stalks are not specified, causing cyclopia. Recent studies showed that the cell adhesion molecule Cdon forms a heteromeric complex with the Hh receptor Patched 1 (Ptc1). This receptor complex binds Hh and enhances signalling activation, indicating that Cdon positively regulates the pathway. Here we show that in the developing zebrafish and chick optic vesicle, in which cdon and ptc1 are expressed with a complementary pattern, Cdon acts as a negative Hh signalling regulator. Cdon predominantly localizes to the basolateral side of neuroepithelial cells, promotes the enlargement of the neuroepithelial basal end-foot and traps Hh protein, thereby limiting its dispersion. This Ptc-independent function protects the retinal primordium from Hh activity, defines the stalk/retina boundary and thus the correct proximo-distal patterning of the eye.

摘要

脊椎动物视泡分化为近端/视柄和远端/神经视网膜涉及中线来源的刺猬因子（Hh）信号传导，该信号传导促进视柄特化。在缺乏Hh信号传导的情况下，视柄无法特化，导致独眼畸形。最近的研究表明，细胞粘附分子Cdon与Hh受体Patched 1（Ptc1）形成异源复合物。这种受体复合物结合Hh并增强信号激活，表明Cdon正向调节该信号通路。在这里，我们表明，在发育中的斑马鱼和鸡视泡中，cdon和ptc1以互补模式表达，Cdon作为Hh信号的负调节因子。Cdon主要定位于神经上皮细胞的基底外侧，促进神经上皮基底端足的扩大并捕获Hh蛋白，从而限制其扩散。这种不依赖Ptc的功能保护视网膜原基免受Hh活性的影响，定义了视柄/视网膜边界，从而确定了眼睛正确的近端-远端模式。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/eaa72f2863df/ncomms5272-f7.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/9d317650050f/ncomms5272-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/f420ba008db8/ncomms5272-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/e6d91e4c66c2/ncomms5272-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/eaa72f2863df/ncomms5272-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/9b5a5cf395d5/ncomms5272-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/13e1ec6694d5/ncomms5272-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/b16761828dba/ncomms5272-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/9d317650050f/ncomms5272-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/f420ba008db8/ncomms5272-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/e6d91e4c66c2/ncomms5272-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f959/4102123/eaa72f2863df/ncomms5272-f7.jpg

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