Department of Pediatrics, Università Politecnica delle Marche, via F. Corridoni 11, 60123 Ancona, Italy.
Division of Pediatric Gastroenterology and Nutrition and Center for Celiac Research, Massachusetts General Hospital for Children, and Celiac Program, Harvard Medical School, 175 Cambridge Street CPZS-574, Boston, MA 02114, USA.
Nat Rev Gastroenterol Hepatol. 2014 Aug;11(8):457-8. doi: 10.1038/nrgastro.2014.119. Epub 2014 Jul 8.
The majority of patients with coeliac disease are undiagnosed, leading to debate about the utility of screening. The heterogeneous clinical presentation, which includes asymptomatic forms, can partially explain the difficulties faced when identifying coeliac disease. Now, Kurppa and colleagues add another element to the debate by strengthening the arguments for general screening.
大多数乳糜泻患者未被诊断,这引发了关于筛查效用的争论。乳糜泻的临床表现呈异质性,包括无症状形式,这在一定程度上解释了在识别乳糜泻时面临的困难。现在,Kurppa 及其同事通过加强对一般筛查的论证,为争论增添了另一个元素。