Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; Applied Biotechnology Division, National Veterinary Research Institute, Vom, Plateau State, Nigeria; Department Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom.
Department of Veterinary Diagnostic and Production Animal Medicine, College of Veterinary Medicine, Iowa State University, Ames, Iowa; Applied Biotechnology Division, National Veterinary Research Institute, Vom, Plateau State, Nigeria; Department Veterinary Public Health and Preventive Medicine, Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria, Kaduna State, Nigeria; The Roslin Institute and The Royal (Dick) School of Veterinary Studies, University of Edinburgh, Midlothian, United Kingdom
Am J Trop Med Hyg. 2014 Oct;91(4):699-704. doi: 10.4269/ajtmh.14-0144. Epub 2014 Jul 7.
Hepatitis E virus (HEV) is an important cause of acute hepatitis in humans. Zoonotic transmission between pigs and humans has been confirmed. Human HEV infection is common in Nigeria; however, characterization of HEV infection in other species was lacking. The objective of this study was to investigate HEV infection in Nigerian pigs. A total of 286 serum samples from six states in Nigeria were tested for presence of anti-HEV IgG. Ninety fecal samples from one of these states (Plateau State) were tested for presence of HEV RNA. The overall prevalence of anti-HEV IgG-positive or suspect-positive pigs was 55.6% (159 of 286) with regional prevalence rates ranging from 36% (9 of 25; Delta State) to 88% (22 of 25; Taraba State). The overall HEV RNA prevalence rate was 76.7% (69 of 90). All polymerase chain reaction-positive samples belonged to HEV genotype 3 based on sequencing. The results indicate that HEV genotype 3 infection is widespread in Nigerian pigs.
戊型肝炎病毒（HEV）是人类急性肝炎的重要病因。已证实其可在猪与人之间发生动物源性传播。HEV 感染在尼日利亚很常见；然而，其他物种的 HEV 感染特征尚不清楚。本研究旨在调查尼日利亚猪中的 HEV 感染情况。检测了来自尼日利亚六个州的 286 份血清样本，以检测抗-HEV IgG 的存在情况。从其中一个州（高原州）的 90 份粪便样本中检测了 HEV RNA 的存在情况。抗-HEV IgG 阳性或疑似阳性猪的总体流行率为 55.6%（286 份中的 159 份），区域流行率范围为 36%（25 份中的 9 份；三角洲州）至 88%（25 份中的 22 份；塔拉巴州）。HEV RNA 的总体流行率为 76.7%（90 份中的 69 份）。所有聚合酶链反应阳性样本均基于测序属于 HEV 基因型 3。结果表明，HEV 基因型 3 感染在尼日利亚猪中广泛流行。
