Sule Waidi Folorunso, Kajogbola Aminat Temitope, Adewumi Moses Olubusuyi
Biological Sciences, Osun State University, Osogbo, Nigeria.
J Immunoassay Immunochem. 2013;34(1):75-82. doi: 10.1080/15321819.2012.683502.
The objectives of this study were to determine the prevalence of anti-hepatitis A virus (HAV) immunoglobulin G (IgG) antibody and associated factors among residents of Osogbo, a town in Nigeria with inadequate environmental sanitation and a shortage of potable water. This is a health facility-based study. Ninety one consenting, asymptomatic attendees of public healthcare facilities in Osogbo, Osun State, Nigeria, were consecutively selected for this study. Plasma samples of the study participants were tested for the presence of anti-HAV IgG using a HAV Ab Competitive Enzyme Immunoassay test kit. Ninety (98.9%) of the participants were seropositive for anti-HAV IgG antibody; group-specific prevalence was also high, but association of participants' variables with the prevalence could not be obtained due to limited sample size and high group-specific prevalence. Since the hepatitis A vaccine is not currently used in Nigeria, the chance is high that the HAV IgG antibody-positive individuals were naturally infected; consequently Osogbo can be described as highly endemic for HAV infection.
本研究的目的是确定在尼日利亚奥索博镇居民中抗甲型肝炎病毒（HAV）免疫球蛋白G（IgG）抗体的流行情况及相关因素。奥索博镇环境卫生差且饮用水短缺。这是一项基于医疗机构的研究。连续选取了尼日利亚奥孙州奥索博镇91名同意参与研究且无症状的公共医疗机构就诊者。使用甲型肝炎病毒抗体竞争酶免疫分析检测试剂盒对研究参与者的血浆样本进行抗HAV IgG检测。90名（98.9%）参与者抗HAV IgG抗体呈血清阳性；按组别的流行率也很高，但由于样本量有限和按组别的流行率高，无法得出参与者变量与流行率之间的关联。由于尼日利亚目前未使用甲型肝炎疫苗，抗HAV IgG抗体阳性个体很可能是自然感染；因此，奥索博镇可被描述为甲型肝炎病毒感染的高流行地区。
