Smearman Erica L, Winiarski D Anne, Brennan Patricia A, Najman Jake, Johnson Katrina C
Emory University Rollins School of Public Health.
Emory University.
Dev Psychopathol. 2015 Feb;27(1):309-18. doi: 10.1017/S0954579414000649. Epub 2014 Jul 8.
Polymorphisms in the oxytocin receptor gene are commonly associated with prosocial behaviors in the extant literature, yet their role in antisocial behaviors has rarely been explored, particularly during the transition from adolescence to early adulthood. We examined a prospective cohort (N = 404), collecting youth, mother, and clinician reports of conduct-disordered and antisocial behavior at ages 15 and 20. The oxytocin receptor gene rs53576 polymorphism was hypothesized to interact with social stress to predict antisocial outcomes. Structural equation modeling results revealed a significant main effect at age 15 (p = .025); those with the G allele exhibited higher levels of conduct problems. Structural equation modeling revealed a significant Gene × Environment interaction at age 20 (p = .029); those with the G allele who experienced high social stress exhibited higher levels of antisocial behavior. Heterozygous (AG) grouping models were compared, and parameter estimations supported G dominant groupings. These novel findings suggest that rs53576 polymorphisms may influence social salience and contribute to risk for antisocial outcomes, particularly under conditions of high social stress.
在现有文献中，催产素受体基因多态性通常与亲社会行为相关，但它们在反社会行为中的作用很少被探讨，尤其是在从青春期到成年早期的过渡阶段。我们研究了一个前瞻性队列（N = 404），收集了青少年、母亲和临床医生关于15岁和20岁时品行障碍和反社会行为的报告。假设催产素受体基因rs53576多态性与社会压力相互作用以预测反社会结果。结构方程模型结果显示在15岁时存在显著的主效应（p = .025）；携带G等位基因的个体表现出更高水平的品行问题。结构方程模型显示在20岁时存在显著的基因×环境交互作用（p = .029）；经历高社会压力且携带G等位基因的个体表现出更高水平的反社会行为。对杂合子（AG）分组模型进行了比较，参数估计支持G显性分组。这些新发现表明，rs53576多态性可能影响社会显著性，并导致反社会结果的风险增加，尤其是在高社会压力条件下。
