Niijima S, Wallace S J
Department of Paediatrics, University Hospital of Wales, Heath Park, Cardiff.
Dev Med Child Neurol. 1989 Apr;31(2):174-80. doi: 10.1111/j.1469-8749.1989.tb03976.x.
Seizure frequency was documented before, during and in some cases after puberty for 12 patients with continuing generalised tonic-clonic seizures (GTCS) and for 14 with complex partial seizures (CPS) who were receiving anti-epileptic drugs. For the patients with GTCS there was a significant increase in seizure frequency during the pubertal growth-spurt, with a subsequent decrease after growth ceased. There appeared to be no relationship between puberty and the frequency of CPS. Both groups were more likely to have suboptimal plasma drug-levels during puberty, suggesting that medication was not the cause of the increased GTCS frequency. Further examination of hormonal levels in relation to frequency of GTCS during puberty could provide a better understanding of the influence of hormones.
记录了12例持续性全身性强直阵挛发作（GTCS）患者和14例接受抗癫痫药物治疗的复杂部分性发作（CPS）患者在青春期前、青春期期间以及部分病例在青春期后的癫痫发作频率。对于GTCS患者，在青春期生长突增期间癫痫发作频率显著增加，生长停止后随后下降。青春期与CPS的发作频率之间似乎没有关系。两组在青春期期间血浆药物水平更可能不理想，这表明药物治疗不是GTCS频率增加的原因。进一步检查青春期期间与GTCS频率相关的激素水平可能有助于更好地理解激素的影响。
