Wyler A R, Lockard J S, Ward A A, Finch C A
Electroencephalogr Clin Neurophysiol. 1976 Nov;41(5):501-12. doi: 10.1016/0013-4694(76)90062-6.
Five patients with seizures poorly controlled by standard anticonvulsant medication, underwent EEG operant conditioning. The operant paradigm reinforced the production of low voltage fast activity while decreasing frequencies below 10 c/sec. Seizure frequency decreased in 2 patients, seizure severity was attenuated in 2 others, and one patient who was only given reinforecement for scalp EMG suppression whowed no change in seizure parameters. Pseudoconditioning and control periods ruled out placebo effects. A rationale for this phenomenon is proposed.
