通过交叉循环在大鼠中传播高血压。
Transmission of hypertension in rats by cross circulation.
作者信息
Zidek W, Ottens E, Heckmann U
机构信息
Medical University, Poliklinik, Münster, FRG.
出版信息
Hypertension. 1989 Jul;14(1):61-5. doi: 10.1161/01.hyp.14.1.61.
Cross circulation was performed in 54 couples of spontaneously hypertensive and normotensive rats. Blood was pumped through two anastomoses between the carotid arteries and external jugular veins in both directions with equal flow rate. In normotensive rats cross-circulated with untreated spontaneously hypertensive rats mean arterial pressure increased by 20.9 +/- 12.2 mm Hg (p less than 0.01). Administration of digoxin antibody in a dose binding 0.25 mg digoxin to the spontaneously hypertensive rats before cross circulation prevented the transmission of hypertension to the normotensive rat, whereas chemical sympathectomy with 6-hydroxydopamine and intravenous injection of inactive Fab fragments had no inhibitory effect. It is concluded that, in this strain of spontaneously hypertensive rats, a circulating hypertensive factor exists. The factor binds to digoxin antibody and is not produced in sympathetic nervous tissue.
对54对自发性高血压大鼠和正常血压大鼠进行了交叉循环实验。血液通过颈动脉和颈外静脉之间的两个吻合口以相同流速双向泵注。在与未治疗的自发性高血压大鼠进行交叉循环的正常血压大鼠中，平均动脉压升高了20.9±12.2 mmHg（p<0.01）。在交叉循环前给自发性高血压大鼠注射能结合0.25 mg地高辛的地高辛抗体，可防止高血压传递给正常血压大鼠，而用6-羟基多巴胺进行化学交感神经切除术和静脉注射无活性的Fab片段则没有抑制作用。得出的结论是，在这种自发性高血压大鼠品系中，存在一种循环性高血压因子。该因子能与地高辛抗体结合，且不是在交感神经组织中产生的。
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