自发性高血压大鼠与正常血压大鼠交叉循环对血压的影响。

Effects on blood pressure of cross circulation between spontaneously hypertensive and normotensive rats.

作者信息

Zidek W, Heckmann U, Losse H, Vetter H

出版信息

Clin Exp Hypertens A. 1986;8(3):347-54. doi: 10.3109/10641968609039609.

DOI:10.3109/10641968609039609

Abstract

In order to examine the role of humoral factors for the development of hypertension in the spontaneously hypertensive rat of the Münster strain (SHR) cross circulation experiments with normotensive Wistar Kyoto rats were performed. Cross circulation between SHR and normotensive rats for 30 min increased mean arterial pressure in the latter by 29.1 +/- 7.6 mm Hg (p less than 0.01). Transmission of hypertension by cross circulation was abolished by nephrectomy, adrenalectomy, volume depletion or chronic salt restriction in the SHR. It is concluded that hypertension in SHR is caused by a circulating hypertensive agent produced in kidneys and adrenals, the secretion of which can be suppressed by volume or salt depletion.

摘要

为了研究体液因素在明斯特品系自发性高血压大鼠（SHR）高血压发生中的作用，进行了与正常血压的Wistar Kyoto大鼠的交叉循环实验。SHR与正常血压大鼠交叉循环30分钟后，后者的平均动脉压升高了29.1±7.6毫米汞柱（p<0.01）。通过肾切除、肾上腺切除、容量耗竭或SHR长期限盐可消除交叉循环导致的高血压传递。结论是，SHR的高血压是由肾脏和肾上腺产生的一种循环性高血压因子引起的，其分泌可被容量或盐耗竭所抑制。