Shinozaki J, Tsuchiya M, Takahashi M, Kawaguchi T, Yamashita T, Kaneta K, Tabuchi S, Oda I
Nihon Gan Chiryo Gakkai Shi. 1989 Jan 20;24(1):32-41.
A retrospective study was performed on 30 cases with choroidal metastases referred to the Cancer Institute Hospital between July 1975 and June 1986. Of these 30 cases, 32 eyes of 26 patients were treated with irradiation of 4.3 MV X-rays or 12 MeV electron beam therapy in the range of 20-60 Gy to restore vision and prevent blindness. The tumor response to radiation therapy confirmed by ophthalmoscopic examination was described as complete, partial or no response. Of the 32 eyes, 31% had complete response, and 47% showed partial response. The overall response rate was 78%. A visual response as defined by marked or partial improvement of visual acuity and/or subjective symptoms was obtained in 16 out of 26 patients (62%). All of these patients were free of recurrence of symptoms in their quality of life. This proved radiotherapy to be a useful modality of treatment for choroidal metastases. No obvious radiation injuries were encountered in this series.
对1975年7月至1986年6月间转诊至癌症研究所医院的30例脉络膜转移瘤患者进行了回顾性研究。在这30例患者中,26例患者的32只眼接受了4.3兆伏X射线或12兆电子伏电子束治疗,照射剂量在20 - 60戈瑞之间,以恢复视力并预防失明。通过眼底镜检查确认的肿瘤对放射治疗的反应被描述为完全缓解、部分缓解或无反应。在这32只眼中,31%为完全缓解,47%为部分缓解。总缓解率为78%。26例患者中有16例(62%)获得了视力反应,定义为视力和/或主观症状明显或部分改善。所有这些患者在生活质量方面均无症状复发。这证明放射治疗是脉络膜转移瘤的一种有效治疗方式。该系列中未遇到明显的放射损伤。