基于葫芦[8]脲的pH响应性超分子前药胶束用于细胞内药物递送。
pH responsive supramolecular prodrug micelles based on cucurbit[8]uril for intracellular drug delivery.
作者信息
Wang Yin, Li Dandan, Wang Haibo, Chen Yangjun, Han Haijie, Jin Qiao, Ji Jian
机构信息
MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
出版信息
Chem Commun (Camb). 2014 Aug 25;50(66):9390-2. doi: 10.1039/c4cc03978e.
PMID:25005141
Abstract
The first attempt of constructing pH responsive supramolecular prodrug micelles based on cucurbit[8]uril is reported. The obtained prodrug micelles are found to be able to inhibit proliferation of cancer cells. It is anticipated that this facile strategy may open a novel avenue for the development of multifunctional drug delivery systems.
摘要
报道了基于葫芦[8]脲构建pH响应性超分子前药胶束的首次尝试。发现所获得的前药胶束能够抑制癌细胞的增殖。预计这种简便的策略可能为多功能药物递送系统的开发开辟一条新途径。
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