Department of Chemical Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 143-701, Korea.
Phys Chem Chem Phys. 2014 Aug 28;16(32):16962-7. doi: 10.1039/c4cp01808g.
This paper proposes the production of yolk-shell structured β-tricalcium phosphate (β-TCP) powders using a spray-drying method, suitable for commercial scale production. Spray-dried precursor powders, consisting of calcium-phosphate salts and each of the various carbon source materials, are combusted in an oxygen atmosphere to obtain a yolk-shell structure. Only dextrin among the carbon source materials investigated shows promise in the production of β-TCP yolk-shell powders. By evaluating their apatite-forming capacity in simulated body fluid, the outstanding bioactivity of β-TCP yolk-shell powders is confirmed: numerous acicular and newly formed hydroxyl carbonate apatite crystals cover the entire β-TCP surface after a single day of soaking. These crystals are observed on both the outer and inner surfaces of the shells, and on the outer surface of the core, which is encouraging for its potential use as a bone grafting material.
本文提出了一种使用喷雾干燥法生产蛋黄壳结构β-磷酸三钙（β-TCP）粉末的方法，适用于商业规模生产。喷雾干燥前体粉末由钙磷酸盐盐和各种碳源材料中的每一种组成，在氧气气氛中燃烧以获得蛋黄壳结构。在所研究的碳源材料中，只有糊精有望用于生产β-TCP 蛋黄壳粉末。通过在模拟体液中评估它们的磷灰石形成能力，证实了β-TCP 蛋黄壳粉末具有出色的生物活性：在浸泡一天后，大量针状和新形成的羟基碳酸磷灰石晶体覆盖整个β-TCP 表面。这些晶体不仅出现在壳的内外表面上，而且出现在核的外表面上，这对于将其用作骨移植材料是令人鼓舞的。
