Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland.
Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland; UFT - Center for Environmental Research and Sustainable Technology, University of Bremen, Leobener Straße, D-28359 Bremen, Germany.
Sci Total Environ. 2014 Sep 15;493:1112-21. doi: 10.1016/j.scitotenv.2014.06.023. Epub 2014 Jul 5.
Beta-blockers (BB) are one of the most widely used pharmaceuticals whose presence in different environmental compartments has already been proven in concentrations of even up to a few μg L(-1). However, our knowledge of their fate in the environment is still scarce. To obtain a better understanding on the environmental behavior of three selected BB comprehensive laboratory experiments assessing their mobility and hydrolytic stability has been conducted. Propranolol, metoprolol and nadolol--the most commonly consumed and detected in environmental samples--were selected as representatives of this group of pharmaceuticals. The objectives of our research were: (i) evaluation of the sorption potential and an explanation of the sorption mechanisms of these compounds onto soil and clay mineral (kaolinite); and (ii) investigation of the hydrolytic stability of these BB according to OECD 111. This comprehensive study supports the Environmental Risk Assessment of these pharmaceuticals.
β受体阻滞剂（BB）是使用最广泛的药物之一，其在不同环境介质中的存在已被证实，浓度甚至高达几微克/升（μg/L）。然而，我们对它们在环境中的归宿的了解仍然很少。为了更好地了解三种选定的β受体阻滞剂在环境中的行为，我们进行了全面的实验室实验，评估它们的迁移性和水解稳定性。普萘洛尔、美托洛尔和纳多洛尔——这是在环境样本中最常被检测到和消耗的β受体阻滞剂——被选为该类药物的代表。我们的研究目的是：（i）评估这些化合物对土壤和粘土矿物（高岭土）的吸附潜力，并解释其吸附机制；（ii）根据 OECD 111 研究这些 BB 的水解稳定性。这项综合研究支持对这些药物进行环境风险评估。
