Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland.
Department of Environmental Analysis, Institute for Environmental and Human Health Protection, Faculty of Chemistry, University of Gdańsk, ul. Wita Stwosza 63, 80-308 Gdańsk, Poland; UFT - Center for Environmental Research and Sustainable Technology, University of Bremen, Leobener Straße, D-28359 Bremen, Germany.
Sci Total Environ. 2014 Sep 15;493:1122-6. doi: 10.1016/j.scitotenv.2014.06.039. Epub 2014 Jun 27.
The increasing consumption of beta-blockers (BB) has caused their presence in the environment to become more noticeable. Even though BB are safe for human and veterinary usage, ecosystems may be exposed to these substances. In this study, three selected BB: propranolol, metoprolol and nadolol were subjected to ecotoxicity study. Ecotoxicity evaluation was based on a flexible ecotoxicological test battery including organisms, representing different trophic levels and complexity: marine bacteria (Vibrio fischeri), soil/sediment bacteria (Arthrobacter globiformis), green algae (Scenedesmus vacuolatus) and duckweed (Lemna minor). All the ecotoxicological studies were supported by instrumental analysis to measure deviation between nominal and real test concentrations. Based on toxicological data from the green algae test (S. vacuolatus) propranolol and metoprolol can be considered to be harmful to aquatic organisms. However, sorption explicitly inhibits the hazardous effects of BB, therefore the risks posed by these compounds for the environment are of minor importance.
随着β受体阻滞剂（BB）用量的增加，其在环境中的存在变得越来越明显。尽管 BB 对人类和兽医使用是安全的，但生态系统仍可能接触到这些物质。在本研究中，选择了三种 BB：普萘洛尔、美托洛尔和纳多洛尔进行了生态毒性研究。生态毒性评价基于一个灵活的生态毒理学测试组合，包括代表不同营养级和复杂性的生物体：海洋细菌（发光菌）、土壤/沉积物细菌（球形节杆菌）、绿藻（栅藻）和浮萍（浮萍）。所有的生态毒理学研究都得到了仪器分析的支持，以测量名义浓度和实际测试浓度之间的偏差。基于绿藻试验（栅藻）的毒理学数据，普萘洛尔和美托洛尔可被认为对水生生物具有危害性。然而，吸附会明显抑制 BB 的有害作用，因此这些化合物对环境造成的风险是次要的。
