Sibanda B L, Blundell T L, Thornton J M
Department of Crystallography, Birkbeck College, London, U.K.
J Mol Biol. 1989 Apr 20;206(4):759-77. doi: 10.1016/0022-2836(89)90583-4.
A systematic classification of beta-hairpin structures which takes into account the polypeptide chain length and hydrogen bonding between the two antiparallel beta-strands is described. We have used this classification of beta-hairpin structures and their specific sequence pattern to derive rules which demonstrate its usefulness in assisting modelling beta-hairpins. These rules can be applied to comparative model building, modelling into electron density and in the prediction of conformation of beta-hairpins to aid protein engineering.
本文描述了一种β-发夹结构的系统分类方法，该方法考虑了多肽链长度以及两条反平行β-链之间的氢键作用。我们利用这种β-发夹结构分类及其特定序列模式推导出一些规则，这些规则证明了其在辅助构建β-发夹模型方面的有用性。这些规则可应用于比较模型构建、电子密度建模以及β-发夹构象预测，以辅助蛋白质工程。
