Zhou Wei, Jiang Zheng, Li Xingang, Xu Yangyang, Shao Zhenyu
Department of Radiation Oncology, Cancer Centre, Qilu Hospital, Shandong University, 44 Wenhuaxi Road, Jinan, 250012, Shandong, China.
J Cancer Res Clin Oncol. 2015 Apr;141(4):575-89. doi: 10.1007/s00432-014-1772-6. Epub 2014 Jul 9.
Malignant gliomas invariably recur after irradiation, showing radioresistance. Meanwhile, cranial irradiation can bring some risk for developing cognitive dysfunction. There is increasing evidence that cytokines play their peculiar roles in these processes. On the one hand, cytokines directly influence the progression of malignant glioma, promoting or suppressing tumor progression. On the other hand, cytokines indirectly contribute to the immunologic response against gliomas, exhibiting pro-inflammatory or immunosuppressive activities. We propose that cytokines are not simply unregulated products from tumor cells or immune cells, but mediators finely adjust the balance between glioma cells and tumor microenvironment after irradiation. The paper, therefore, focuses on the changes of cytokines after irradiation, analyzing how these mediate the response of tumor cells and normal cells to irradiation. In addition, cytokine-based immunotherapeutic strategies, accompanied with irradiation, for the treatment of gliomas are also discussed.
恶性胶质瘤在放疗后总是会复发，表现出放射抗性。与此同时，颅脑放疗会带来一些发生认知功能障碍的风险。越来越多的证据表明，细胞因子在这些过程中发挥着独特作用。一方面，细胞因子直接影响恶性胶质瘤的进展，促进或抑制肿瘤进展。另一方面，细胞因子间接促进针对胶质瘤的免疫反应，表现出促炎或免疫抑制活性。我们认为，细胞因子并非简单地是肿瘤细胞或免疫细胞不受调控的产物，而是放疗后精细调节胶质瘤细胞与肿瘤微环境之间平衡的介质。因此，本文聚焦于放疗后细胞因子的变化，分析它们如何介导肿瘤细胞和正常细胞对放疗的反应。此外，还讨论了基于细胞因子的免疫治疗策略联合放疗用于治疗胶质瘤的情况。
