School of Medicine, South China University of Technology, Guangzhou, 510006, China.
Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, No. 106, Zhongshan Second Road, Guangzhou, 510080, Guangdong, People's Republic of China.
J Cancer Res Clin Oncol. 2021 Nov;147(11):3343-3357. doi: 10.1007/s00432-021-03762-9. Epub 2021 Sep 1.
The anti-inflammatory environment of glioma reduces the efficacy of immunotherapies. Therefore, it is vital to transform the immunosuppressive microenvironment of glioma into a pro-inflammatory environment. Sialic acid-binding immunoglobulin-type lectins (Siglecs) can serve as immune checkpoint targets that enhance the anti-tumor immune response. However, the roles of Siglecs in the glioma microenvironment are unknown. This study was conducted to identify targets to inhibit the anti-inflammatory environment to improve therapeutic outcomes in patients with glioma.
We analyzed the regulatory effect of prognosis-related Siglecs identified from data available in The Cancer Genome Atlas database (TCGA) and China Glioma Genome Atlas Data portal on the immunosuppressive microenvironment of glioma. The effects of prognosis-related Siglecs on the glioma microenvironment were investigated by determining the Pearson correlation coefficients of the Siglecs in transcriptome data from the TCGA database.
Siglec-1, -9, -10, and -14 were closely associated with the prognosis of patients with glioma. The expression of these four Siglecs was significantly increased in the high-risk group and positively correlated with anti-inflammatory cytokine levels in the glioma microenvironment.
Our study provides insights into the effects of prognosis-related Siglecs in glioma immunotherapy, suggesting that targeted prognosis-related Siglecs can modify the microenvironment of glioma and improve the sensitivity of patients with glioma to immunotherapy.
脑胶质瘤的抗炎环境降低了免疫疗法的疗效。因此，将脑胶质瘤的免疫抑制微环境转化为促炎环境至关重要。唾液酸结合免疫球蛋白型凝集素（Siglecs）可以作为免疫检查点的靶点，增强抗肿瘤免疫反应。然而，Siglecs 在脑胶质瘤微环境中的作用尚不清楚。本研究旨在确定抑制抗炎环境的靶点，以提高脑胶质瘤患者的治疗效果。
我们分析了从癌症基因组图谱数据库（TCGA）和中国脑胶质瘤基因组图谱数据门户中获得的与预后相关的 Siglecs 的调节作用对脑胶质瘤的免疫抑制微环境的影响。通过确定 TCGA 数据库中转录组数据中 Siglecs 的 Pearson 相关系数来研究与预后相关的 Siglecs 对脑胶质瘤微环境的影响。
Siglec-1、-9、-10 和-14 与脑胶质瘤患者的预后密切相关。这四个 Siglecs 的表达在高危组中显著增加，并与脑胶质瘤微环境中的抗炎细胞因子水平呈正相关。
我们的研究深入了解了与预后相关的 Siglecs 在脑胶质瘤免疫治疗中的作用，表明靶向与预后相关的 Siglecs 可以改变脑胶质瘤的微环境，提高脑胶质瘤患者对免疫治疗的敏感性。
