黄腐酚是一种来自啤酒花的异戊烯基化查尔酮，它能抑制胆固醇酯转运蛋白。
Xanthohumol, a prenylated chalcone from Humulus lupulus L., inhibits cholesteryl ester transfer protein.
作者信息
Hirata Hiroshi, Takazumi Koji, Segawa Shuichi, Okada Yukio, Kobayashi Naoyuki, Shigyo Tatsuro, Chiba Hitoshi
机构信息
Frontier Laboratories of Value Creation, Sapporo Breweries Ltd., 10 Okatohme, Yaizu, Shizuoka 425-0013, Japan.
Faculty of Health Science, Hokkaido University School of Medicine, Kita 12, Nishi 5, Kita-ku, Sapporo 060-0812, Japan.
出版信息
Food Chem. 2012 Oct 1;134(3):1432-7. doi: 10.1016/j.foodchem.2012.03.043. Epub 2012 Mar 19.
High density lipoprotein (HDL)-cholesterol levels are correlated with a low risk of atherosclerosis. The inhibition of cholesteryl ester transfer protein (CETP), which catalyses cholesterol transfer between lipoproteins, leads to an increase in HDL-cholesterol and is expected to be the next anti-atherogenic target. This study revealed that xanthohumol, a prenylated chalcone, showed the highest inhibition against CETP from screening of natural products in various plants. We investigated the inhibitory activity of some chalcones and flavanones. Naringenin chalcone showed weak CETP inhibition compared with xanthohumol. In addition, isoxanthohumol and naringenin drastically decreased the inhibitory activity. These results suggest that the prenyl group and chalcone structure of xanthohumol were responsible for the CETP inhibitory activity.
高密度脂蛋白（HDL）胆固醇水平与动脉粥样硬化低风险相关。催化脂蛋白间胆固醇转移的胆固醇酯转运蛋白（CETP）受到抑制会导致HDL胆固醇增加，有望成为下一个抗动脉粥样硬化靶点。本研究表明，在对各种植物中的天然产物进行筛选时，异戊烯基化查耳酮黄腐酚对CETP的抑制作用最强。我们研究了一些查耳酮和黄烷酮的抑制活性。与黄腐酚相比，柚皮素查耳酮对CETP的抑制作用较弱。此外，异黄腐酚和柚皮素会大幅降低抑制活性。这些结果表明，黄腐酚的异戊烯基和查耳酮结构是其CETP抑制活性的原因。
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