来自啤酒花的新型异戊烯基化双查耳酮和查耳酮及其醌还原酶诱导活性。
Novel prenylated bichalcone and chalcone from Humulus lupulus and their quinone reductase induction activities.
作者信息
Yu Liyan, Zhang Fuxian, Hu Zhijuan, Ding Hui, Tang Huifang, Ma Zhongjun, Zhao Xiaofeng
机构信息
Institute of Marine Biology & Natural Products, Ocean College, Zhejiang University, No. 866 Yuhangtang Rd., Hangzhou 310058, China.
Quzhou Academy of Agricultural Sciences (Zhejiang Province), Quzhou 324000, China.
出版信息
Fitoterapia. 2014 Mar;93:115-20. doi: 10.1016/j.fitote.2013.12.019. Epub 2014 Jan 4.
A new prenylated chalcone xanthohumol M (1), a novel prenylated bichalcone humulusol (2) and six known chalcones (3-8) were found from Humulus lupulus. Their structures were determined by spectroscopic methods. All the chalcones' electrophilic abilities were assessed by GSH (glutathione) rapid screening, and their QR (quinone reductase) induction activities were evaluated using hepa 1c1c7 cells. The results of electrophilic assay and QR induction activity assay were quite well. New compounds 1 and 2, along with some known prenylated chalcones, displayed certain QR induction activity.
从啤酒花中发现了一种新的异戊烯基化查耳酮黄腐酚M（1）、一种新型异戊烯基化双查耳酮葎草酮（2）以及六种已知的查耳酮（3 - 8）。通过光谱方法确定了它们的结构。所有查耳酮的亲电能力通过谷胱甘肽（GSH）快速筛选进行评估，并且使用hepa 1c1c7细胞评估它们的醌还原酶（QR）诱导活性。亲电测定和QR诱导活性测定的结果相当不错。新化合物1和2以及一些已知的异戊烯基化查耳酮表现出一定的QR诱导活性。
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