脊柱后纵韧带骨化的遗传学：一篇小型综述
Genetics of ossification of the posterior longitudinal ligament of the spine: a mini review.
作者信息
Ikegawa Shiro
机构信息
Laboratory of Bone and Joint Diseases, Center for Genomic Medicine, RIKEN, Tokyo, Japan.
出版信息
J Bone Metab. 2014 May;21(2):127-32. doi: 10.11005/jbm.2014.21.2.127. Epub 2014 May 31.
Abstract
Ossification of the posterior longitudinal ligament of the spine (OPLL) is a common disease in aging populations and sometimes results in serious neurological problems due to compression of the spinal cord and nerve roots. OPLL is a multi-factorial (polygenic) disease controlled by genetic and environmental factors. Studies searching for the genetic component of OPLL, using linkage and association analyses, are in progress and several susceptibility genes have been reported. This paper reviews the recent progress in the genetic study of OPLL and comments on its future task.
摘要
脊柱后纵韧带骨化症（OPLL）是老年人群中的常见疾病，有时会因脊髓和神经根受压而导致严重的神经问题。OPLL是一种受遗传和环境因素控制的多因素（多基因）疾病。目前正在进行利用连锁分析和关联分析寻找OPLL遗传成分的研究，并且已经报道了几个易感基因。本文综述了OPLL遗传研究的最新进展，并对其未来任务进行了评论。
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