Nabeshima T, Itoh K, Kawashima K, Kameyama T
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences Meijo University, Nagoya, Japan.
Pharmacol Biochem Behav. 1989 Mar;32(3):787-90. doi: 10.1016/0091-3057(89)90034-8.
A role played by serotonergic neuronal system in cycloheximide (CXM)-induced amnesia was studied in mice using a step-down passive avoidance task. CXM (30 mg/kg SC) given immediately after training caused impairment of memory. Nonselective serotonin (5-HT) antagonist methysergide and selective 5-HT2 antagonist ritanserin significantly attenuated impairment of memory caused by CXM. 5-HT1 antagonist (+/-)-pindolol had no effect on CXM-induced amnesia. The antiamnesic effect of ritanserin on CXM-induced amnesia was antagonized by 5-HT (ICV), but not by nonselective 5-HT agonist 5-methoxy-N,N-dimethyltryptamine and 5-HT1A selective agonist 8-hydroxy-2-(di-n-propylamino)tetralin at the dose level which did not cause the memory disruption. Scopolamine antagonized the antiamnesic effects of methysergide and ritanserin on CXM-induced amnesia. These results suggest that 5-HT2 receptors and cholinergic neuronal system may play an important role in memory formation.
采用被动回避跳台实验，研究了血清素能神经系统在环己酰亚胺（CXM）诱导的小鼠记忆缺失中的作用。训练后立即皮下注射CXM（30mg/kg）会导致记忆损伤。非选择性血清素（5-HT）拮抗剂麦角新碱和选择性5-HT2拮抗剂利坦色林可显著减轻CXM所致的记忆损伤。5-HT1拮抗剂（±）-吲哚洛尔对CXM诱导的记忆缺失无影响。利坦色林对CXM诱导的记忆缺失的抗遗忘作用可被脑室内注射5-HT拮抗，但在不引起记忆破坏的剂量水平下，非选择性5-HT激动剂5-甲氧基-N，N-二甲基色胺和5-HT1A选择性激动剂8-羟基-2-（二正丙基氨基）四氢萘不能拮抗。东莨菪碱可拮抗麦角新碱和利坦色林对CXM诱导的记忆缺失的抗遗忘作用。这些结果表明，5-HT2受体和胆碱能神经系统可能在记忆形成中起重要作用。
