Hsieh M T, Wu C R, Hsieh C C
Institute of Chinese Pharmaceutical Sciences, China Medical College, Taichung, Taiwan, Republic of China.
Pharmacol Biochem Behav. 1998 Jun;60(2):337-43. doi: 10.1016/s0091-3057(97)00591-1.
The effect of p-hydroxybenzyl alcohol (HBA) on cycloheximide (CXM)-induced impairment in the step-through passive avoidance task was investigated in rats and compared to the effect of the nootropic piracetam. HBA and piracetam significantly counteracted the CXM-induced shortening of retention latencies. The effect of HBA was a bell-shaped dose-response curve with a maximal effect of 5 mg/kg. The counteractive effect of HBA was not depressed by either scopolamine or mecamylamine. The serotonin (5-HT) releaser, p-chloroamphetamine, and presursor, 5-hydroxytryptophan, significantly antagonized the counteractive effect of HBA on the CXM-induced shortening of retention latencies. Furthermore, the counteractive effect was also inhibited by the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) and the 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2 aminopropane [(+/-)-DOI], but potentiated by the 5-HT1 receptor antagonist (+/-)-pindolol and the 5-HT2 receptor antagonist ritanserin. There results suggest that the beneficial effect of HBA on CXM-induced impairment is amplified by treatment with serotonergic receptor antagonists but reduced by serotonergic 5-HT1A and 5-HT2 receptor agonists, and insensitive to cholinergic manipulations.
研究了对羟基苯甲醇（HBA）对大鼠穿梭箱被动回避任务中放线菌酮（CXM）诱导损伤的影响，并与促智药吡拉西坦的作用进行了比较。HBA和吡拉西坦均显著抵消了CXM诱导的记忆潜伏期缩短。HBA的作用呈钟形剂量反应曲线，最大效应为5mg/kg。东莨菪碱或美加明均未抑制HBA的对抗作用。5-羟色胺（5-HT）释放剂对氯苯丙胺和前体5-羟色氨酸显著拮抗HBA对CXM诱导的记忆潜伏期缩短的对抗作用。此外，5-HT1A受体激动剂8-羟基-2-（二正丙基氨基）四氢萘（8-OH-DPAT）和5-HT2受体激动剂1-（2,5-二甲氧基-4-碘苯基）-2-氨基丙烷[（+/-）-DOI]也抑制了这种对抗作用，但5-HT1受体拮抗剂（+/-）-吲哚洛尔和5-HT2受体拮抗剂利坦色林则增强了这种作用。这些结果表明，HBA对CXM诱导损伤的有益作用在使用5-羟色胺能受体拮抗剂治疗时会增强，但在使用5-HT1A和5-HT2受体激动剂时会减弱，并且对胆碱能操作不敏感。
