De Stefani Antonella, Boffano Paolo, Bongioannini Guido
From the *Division of Otorhinolaryngology, Ospedale Mauriziano Umberto I, Turin, Italy; and †Turin, Italy.
J Craniofac Surg. 2014 Jul;25(4):e371-3. doi: 10.1097/SCS.0000000000000860.
The orbit represents a rare site of presentation of non-Hodgkin lymphoma. The diagnosis and management of orbital lymphomas may be challenging because these neoplasms present few specific features.
A 69-year-old woman presented with painless swelling of the left lower eyelid of 5 years' duration. Magnetic resonance imaging and incisional biopsy were necessary to establish a diagnosis of orbital diffuse large B-cell lymphoma. Staging was completed, thanks to a computed tomographic study of the chest and abdomen.
The patient underwent systemic chemotherapy with 1 regimen (doxorubicin, vincristine, prednisone, 6-mercaptopurine, and methotrexate), followed by 1 R-COMP-14 regimen (rituximab, cyclophosphamide, nonpegylated liposome-encapsulated doxorubicin, vincristine, and prednisone). Complete resolution of the disease was obtained.
Although not typically performed by the head and neck surgeon, an understanding of the staging process is crucial for multidisciplinary management of orbital lymphomas.
眼眶是非霍奇金淋巴瘤罕见的发病部位。眼眶淋巴瘤的诊断和治疗可能具有挑战性，因为这些肿瘤几乎没有特异性特征。
一名69岁女性，左眼下睑无痛性肿胀5年。需行磁共振成像和切开活检以确诊眼眶弥漫性大B细胞淋巴瘤。借助胸部和腹部的计算机断层扫描研究完成了分期。
患者接受了1个疗程的全身化疗（多柔比星、长春新碱、泼尼松、6-巯基嘌呤和甲氨蝶呤），随后接受1个R-COMP-14疗程（利妥昔单抗、环磷酰胺、非聚乙二醇化脂质体包裹的多柔比星、长春新碱和泼尼松）。疾病完全缓解。
尽管眼眶淋巴瘤的分期通常并非由头颈外科医生完成，但了解分期过程对于眼眶淋巴瘤的多学科管理至关重要。
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