Suresh Preeti K, Sah Abhishek K
University Institute of Pharmacy, Faculty of Technology, Pt. Ravishankar Shukla University , Raipur-492010, (C.G.) , India +07712262832 ;
Expert Opin Drug Deliv. 2014 Nov;11(11):1747-68. doi: 10.1517/17425247.2014.938045. Epub 2014 Jul 9.
Many therapeutic strategies have been adopted in the treatment of anterior uveitis, and it includes corticosteroids and NSAIDs. But, the successful delivery of these drugs is restricted due to limitations of conventional formulation. This review emphasizes on the possible benefits and strategies for development of various novel nanocarriers.
The article explores the various polymers involved in the preparation of novel nanocarriers like polymeric nanoparticles, micelles, microemulsion, liposomes and cubosomes. Reported clinical experimental findings are screened and also discussed in this review.
The principle behind the development of different nanocarriers is to overcome the limitations imposed by conventional formulations. Several efforts have been made by the researchers in achieving these objectives, but the major challenge with nanosystems remains the requirement of excipients that have unknown or objectionable toxicity profile and are not approved by regulatory authorities. This review is an attempt to provide comprehensive information for the scientists working in the concerned research area.
在前葡萄膜炎的治疗中已采用了多种治疗策略，包括使用皮质类固醇和非甾体抗炎药。但是，由于传统制剂的局限性，这些药物的成功递送受到限制。本综述着重探讨了各种新型纳米载体开发的潜在益处和策略。
本文探讨了用于制备新型纳米载体的各种聚合物，如聚合物纳米颗粒、胶束、微乳、脂质体和立方液晶。本综述筛选并讨论了已报道的临床实验结果。
不同纳米载体开发背后的原理是克服传统制剂带来的局限性。研究人员为实现这些目标做出了多项努力，但纳米系统面临的主要挑战仍然是辅料的要求，这些辅料具有未知或令人反感的毒性特征，且未获得监管机构的批准。本综述旨在为相关研究领域的科学家提供全面信息。
