Srivastava Anjali, Price Douglas K, Figg William D
Genitourinary Malignancies Branch; Center for Cancer Research; National Cancer Institute; Bethesda, MD USA.
Cancer Biol Ther. 2014 Oct;15(10):1293-5. doi: 10.4161/cbt.29694. Epub 2014 Jul 9.
Gene fusions involving ETS transcription factors (predominantly ERG and ETV1) and PTEN deletions are prevalent in the prostate cancer genome. This report describes a novel mouse model that overexpresses ERG and lacks PTEN with the majority of mice developing prostate tumors by 6 mo. Biological mechanisms suggest increased/altered binding of the male hormone receptor in the genome. This model will be useful in pre-clinical evaluation of new drugs targeting these common prostate cancer genomic alterations.
涉及ETS转录因子(主要是ERG和ETV1)的基因融合以及PTEN缺失在前列腺癌基因组中很常见。本报告描述了一种新型小鼠模型,该模型过表达ERG且缺乏PTEN,大多数小鼠在6个月时会发生前列腺肿瘤。生物学机制表明基因组中雄性激素受体的结合增加/改变。该模型将有助于针对这些常见前列腺癌基因组改变的新药的临床前评估。