Jastrzebski Mikolaj, Bala Aleksandra
Psychiatr Pol. 2013 Nov-Dec;47(6):1157-67.
Psilocybin is a substance of natural origin, occurring in hallucinogenic mushrooms (most common in the Psilocybe family). After its synthesis in 1958 research began on its psychoactive properties, particularly strong effects on visual perception and spatial orientation. Due to the very broad spectrum of psilocybin effects research began on the different ranges of its actions--including the effect on physiological processes (such as eye saccada movements). Neuro-imaging and neurophysiological research (positron emission tomography-PET and electroencephalography-EEG), indicate a change in the rate of metabolism of the brain and desync cerebral hemispheres. Experimental studies show the changes in visual perception and distortion from psilocybin in the handwriting style of patients examined. There are widely described subjective experiences reported by the subjects. There are also efforts to apply testing via questionnaire on people under the influence of psilocybin, in the context of the similarity of psilocybin-induced state to the initial stages of schizophrenia, as well as research aimed at creating an 'artificial' model of the disease.
裸盖菇素是一种天然存在的物质,存在于致幻蘑菇中(最常见于裸盖菇属)。1958年其合成后,人们开始研究其精神活性特性,尤其是对视觉感知和空间定向的强烈影响。由于裸盖菇素的作用范围非常广泛,人们开始研究其不同作用范围——包括对生理过程的影响(如眼球跳动)。神经成像和神经生理学研究(正电子发射断层扫描-PET和脑电图-EEG)表明大脑代谢率发生变化且大脑半球不同步。实验研究表明,接受检查的患者在服用裸盖菇素后,其手写风格出现视觉感知变化和扭曲。受试者广泛描述了主观体验。此外,鉴于裸盖菇素诱发的状态与精神分裂症初期的相似性,人们还努力通过问卷对受裸盖菇素影响的人进行测试,以及开展旨在创建该疾病“人工”模型的研究。