Metastasio Antonio, Prevete Elisabeth, Venturini Sofia, Garofalo Andrea, Cecconello Beatrice, De Pisapia Nicola, Corazza Ornella
Department of Clinical, Pharmacological and Biological Sciences, College Lane, University of Hertfordshire, Hatfield, United Kingdom.
Azienda USL Umbria 2, Terni, Italy.
Front Psychol. 2025 Apr 25;16:1455902. doi: 10.3389/fpsyg.2025.1455902. eCollection 2025.
Considering the increasing evidence supporting psilocybin's efficacy in therapeutic settings, it is essential to deepen our understanding of its subjective meanings and effects to enhance its integration into psychotherapy. Current knowledge is primarily based on psychometric assessments or unstructured personal reports, leaving a gap in the qualitative analysis of subjective psychedelic experiences and the resulting changes.
This study aimed to describe the subjective psychedelic experience with psilocybin in a structured, objective, and non-judgmental way (), while exploring its potential clinical applications.
A phenomenological qualitative approach, integrating interpretative phenomenological analysis (IPA) and the dynamic analysis (PHD) method, was used to analyze self-reported psilocybin experiences. Participants who met the inclusion criteria of being healthy adults and who had experienced psilocybin without any other substances were recruited through convenience sampling. Semi-structured interviews explored dimensions such as emotions, bodily sensations, perception of time and space, relationships, values, and enduring transformation. Data were analyzed using thematic coding.
Ten interviews were carried out with voluntary participants. All the interviewees reported enhanced emotional and interpersonal sensitivity, increased empathy, a deeper connection to others, and a heightened ability to resolve personal issues as well as long-lasting insights into their lives and values. Participants also showed profound changes in behavior, attitudes, and interests, indicative of the potential for psilocybin to catalyze significant personal growth and development.
This study highlights the transformative potential of psilocybin experiences and their relevance to psychotherapeutic practices. By employing phenomenological methods, we offer a structured understanding of these states, which could be used in future to provide guidance for their integration into therapy by giving a better insight into psychedelic experience.
鉴于越来越多的证据支持裸盖菇素在治疗环境中的疗效,加深我们对其主观意义和效果的理解对于将其更好地融入心理治疗至关重要。目前的知识主要基于心理测量评估或无结构的个人报告,在对主观迷幻体验及其产生的变化进行定性分析方面存在空白。
本研究旨在以结构化、客观且无偏见的方式描述使用裸盖菇素后的主观迷幻体验( ),同时探索其潜在的临床应用。
采用现象学定性方法,将解释现象学分析(IPA)和动态分析(PHD)方法相结合,对自我报告的裸盖菇素体验进行分析。通过便利抽样招募符合健康成年人且仅使用过裸盖菇素而未使用其他物质这一纳入标准的参与者。半结构化访谈探讨了情绪、身体感觉、时间和空间感知、人际关系、价值观以及持久转变等方面。使用主题编码对数据进行分析。
对10名自愿参与者进行了访谈。所有受访者都报告称情绪和人际敏感性增强、同理心增加、与他人的联系更深入、解决个人问题的能力提高,以及对自己的生活和价值观有了更深刻的洞察。参与者在行为、态度和兴趣方面也表现出了深刻的变化,表明裸盖菇素具有促进显著个人成长和发展的潜力。
本研究强调了裸盖菇素体验的变革潜力及其与心理治疗实践的相关性。通过采用现象学方法,我们对这些状态提供了结构化的理解,未来可用于通过更好地洞察迷幻体验为将其融入治疗提供指导。