Biehl Stefanie C, Gschwendtner Kathrin M, Guhn Anne, Müller Laura D, Reichert Susanne, Heupel Julia, Reif Andreas, Deckert Jürgen, Herrmann Martin J, Jacob Christian P
Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Füchsleinstraße 15, 97080, Würzburg, Germany,
Atten Defic Hyperact Disord. 2015 Mar;7(1):19-25. doi: 10.1007/s12402-014-0148-8. Epub 2014 Jul 10.
Both attention-deficit/hyperactivity disorder (ADHD) and catechol-O-methyltransferase (COMT) genotype have been linked to altered dopaminergic transmission and possible impairment in frontal lobe functioning. This study offers an investigation of a possible interaction between ADHD diagnosis and COMT genotype on measures of working memory and executive function. Thirty-five adults with ADHD, who were recruited from the ADHD outpatient clinic at the Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, and thirty-five matched healthy controls completed the Digit Span test and the Stroop Color Word Test. While there were no main effects of ADHD or COMT, the two factors interacted on both Digit Span subtests with the two groups' met/met carriers showing significantly different performance on the Digit Span Forward subtest and the val/val carriers showing significantly different performance on the Digit Span Backward subtest. Findings provide preliminary support for a differential impact of COMT genotype on working memory measures in adult patients with ADHD compared to healthy controls.
注意力缺陷多动障碍（ADHD）和儿茶酚-O-甲基转移酶（COMT）基因型均与多巴胺能传递改变及额叶功能可能受损有关。本研究探讨了ADHD诊断与COMT基因型在工作记忆和执行功能测量方面可能存在的相互作用。35名患有ADHD的成年人（从维尔茨堡大学精神病学、身心医学与心理治疗系的ADHD门诊招募）和35名匹配的健康对照者完成了数字广度测试和斯特鲁普色词测试。虽然ADHD或COMT没有主效应，但这两个因素在数字广度测试的两个子测试中存在相互作用，两组的met/met携带者在顺背数字广度子测试中表现出显著差异，而val/val携带者在倒背数字广度子测试中表现出显著差异。研究结果为COMT基因型对成年ADHD患者工作记忆测量的影响与健康对照者不同提供了初步支持。
