State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences , Changchun 130022, People's Republic of China.
ACS Appl Mater Interfaces. 2014 Aug 13;6(15):12761-70. doi: 10.1021/am502718b. Epub 2014 Jul 10.
Multifunctional BaGdF5 nanospheres with mesoporous, luminescent, and magnetic properties have been successfully synthesized with the assistance of trisodium citrate by a hydrothermal method. The mesoporous structure is revealed by scanning electron microscope and transmission electron microscope images as well as N2 adsorption-desorption isotherm. The as-synthesized BaGdF5 nanospheres exhibit an intense broad bluish emission (centered at 450 nm) under the excitation of 390 nm, which might originate from the CO2·(-) radical-related defect produced by Cit(3-) groups. It is also shown that these BaGdF5 nanospheres brightened the T1-weighted images, suggesting that they could act as T1 contrast agents for magnetic resonance imaging. Using metformin hydrochloride as the model drug, the luminescent porous spheres show good drug storage/release capability. Furthermore, the emission intensity varies as a function of the cumulative drug release, making the drug-carrying system easily trackable and monitorable by detecting the luminescence intensity. Additionally, the paramagnetic property, originating from the unpaired electrons of Gd(3+) ions, opens the possibility of directing the magnetic targeted carrier to the pathological site by magnetic field gradient.
具有介孔、发光和磁性的多功能 BaGdF5 纳米球已成功通过水热法在柠檬酸三钠的辅助下合成。介孔结构通过扫描电子显微镜和透射电子显微镜图像以及 N2 吸附-脱附等温线揭示。所合成的 BaGdF5 纳米球在 390nm 的激发下表现出强烈的宽蓝色发射（中心在 450nm 处），这可能源于 Cit（3-）基团产生的 CO2·（-）自由基相关缺陷。还表明，这些 BaGdF5 纳米球使 T1 加权图像变亮，表明它们可以用作磁共振成像的 T1 对比剂。使用盐酸二甲双胍作为模型药物，发光多孔球显示出良好的药物储存/释放能力。此外，发光强度随累积药物释放而变化，使得通过检测发光强度可以轻松跟踪和监测载药系统。此外，来自 Gd（3+）离子未配对电子的顺磁性质使得通过磁场梯度将磁性靶向载体引导到病理部位成为可能。
