State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China.
Langmuir. 2013 Jan 29;29(4):1286-94. doi: 10.1021/la304551y. Epub 2013 Jan 14.
Hollow and porous structured GdVO(4):Dy(3+) spheres were fabricated via a facile self-sacrificing templated method. The large cavity allows them to be used as potential hosts for therapeutic drugs, and the porous feature of the shell allows guest molecules to easily pass through the void space and surrounding environment. The samples show strong yellow-green emission of Dy(3+) (485 nm, (4)F(9/2) → (6)H(15/2); 575 nm, (4)F(9/2) → (6)H(13/2)) under UV excitation. The emission intensity of GdVO(4):Dy(3+) was weakened after encapsulation of anticancer drug (doxorubicin hydrochloride, DOX) and gradually restored with the cumulative released time of DOX. These hollow spheres were nontoxic to HeLa cells, while DOX-loaded samples led to apparent cytotoxicity as a result of the sustained release of DOX. ICP measurement indicates that free toxic Gd ions can hardly dissolate from the matrix. The endocytosis process of DOX-loaded hollow spheres is observed using confocal laser scanning microscopy (CLSM). Furthermore, GdVO(4):Dy(3+) hollow spheres can be used for T(1)-weighted magnetic resonance (MR) imaging. These results implicate that the luminescent GdVO(4):Dy(3+) spheres with hollow and porous structure are promising platforms for drug storage/release and MR imaging.
通过简便的自牺牲模板法制备了具有中空多孔结构的 GdVO(4):Dy(3+) 球体。大空腔允许它们被用作治疗药物的潜在载体，而壳的多孔特性允许客体分子容易地通过空隙空间和周围环境。样品在紫外光激发下显示出 Dy(3+) 的强烈黄绿光发射(485nm，(4)F(9/2)→(6)H(15/2)；575nm，(4)F(9/2)→(6)H(13/2))。封装抗癌药物(盐酸多柔比星，DOX)后，GdVO(4):Dy(3+) 的发射强度减弱，并随着 DOX 的累积释放时间逐渐恢复。这些中空球体对 HeLa 细胞无毒性，而负载 DOX 的样品由于 DOX 的持续释放导致明显的细胞毒性。ICP 测量表明，游离的有毒 Gd 离子几乎不能从基质中溶解。使用共聚焦激光扫描显微镜(CLSM)观察了 DOX 负载的中空球体的内吞过程。此外，GdVO(4):Dy(3+)中空球体可用于 T(1)加权磁共振(MR)成像。这些结果表明，具有中空多孔结构的发光 GdVO(4):Dy(3+) 球体是药物储存/释放和磁共振成像的有前途的平台。
