Herhaus Lina, Sapkota Gopal P
MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH Scotland, United Kingdom.
MRC Protein Phosphorylation and Ubiquitylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee, DD1 5EH Scotland, United Kingdom.
Cell Signal. 2014 Oct;26(10):2186-92. doi: 10.1016/j.cellsig.2014.06.012. Epub 2014 Jul 5.
The members of the transforming growth factor beta (TGFβ) family of cytokines, including bone morphogenetic proteins (BMP), play fundamental roles in development and tissue homeostasis. Hence, aberrant TGFβ/BMP signalling is associated with several human diseases such as fibrosis, bone and immune disorders, cancer progression and metastasis. Consequently, targeting TGFβ signalling for intervention potentially offers therapeutic opportunities against these diseases. Many investigations have focussed on understanding the molecular mechanisms underpinning the regulation of TGFβ signalling. One of the key areas has been to investigate the regulation of the protein components of the TGFβ/BMP signal transduction pathways by ubiquitylation and deubiquitylation. In the last 15years, extensive research has led to the discovery and characterisation of several E3 ubiquitin ligases that influence the TGFβ pathway. However, the research on DUBs regulating the TGFβ pathway has received prominence only recently and is still an emerging field. This review will provide a concise summary of our current understanding of how DUBs regulate TGFβ signalling.
细胞因子转化生长因子β（TGFβ）家族的成员，包括骨形态发生蛋白（BMP），在发育和组织稳态中发挥着重要作用。因此，异常的TGFβ/BMP信号传导与多种人类疾病相关，如纤维化、骨骼和免疫紊乱、癌症进展和转移。因此，针对TGFβ信号传导进行干预可能为治疗这些疾病提供机会。许多研究都集中在理解TGFβ信号传导调控的分子机制上。其中一个关键领域是研究泛素化和去泛素化对TGFβ/BMP信号转导途径蛋白质成分的调控。在过去15年里，广泛的研究导致发现并鉴定了几种影响TGFβ途径的E3泛素连接酶。然而，关于调节TGFβ途径的去泛素化酶（DUBs）的研究直到最近才受到关注，并且仍然是一个新兴领域。本综述将简要总结我们目前对DUBs如何调节TGFβ信号传导的理解。
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