Smad 的单泛素化和去泛素化对 TGF-β 信号转导的调控。
Regulation of TGF-β signal transduction by mono- and deubiquitylation of Smads.
机构信息
Department of Biomedical Sciences, University of Padova, Padova, Italy.
出版信息
FEBS Lett. 2012 Jul 4;586(14):1913-20. doi: 10.1016/j.febslet.2012.03.037. Epub 2012 Mar 24.
Abstract
Polyubiquitylation leading to proteasomal degradation is a well-established mechanism for regulating TGF-β signal transduction components such as receptors and Smads. Recently, an equally important role was suggested for monoubiquitylation of both Smad4 and receptor-associated Smads that regulates their function without protein degradation. Monoubiquitylation of Smads was discovered following the identification of deubiquitylases required for TGF-β signaling, suggesting that continuous cycles of Smad mono- and deubiquitylation are required for proper TGF-β signal transduction. Here we summarize and discuss recent work on Smad mono- and deubiquitylation.
摘要
多泛素化导致蛋白酶体降解是调节 TGF-β信号转导成分（如受体和 Smads）的一种成熟机制。最近，Smad4 和受体相关 Smads 的单泛素化在调节它们的功能而不导致蛋白降解方面也被认为具有同样重要的作用。Smads 的单泛素化是在鉴定出 TGF-β信号所必需的去泛素化酶后发现的，这表明 Smad 单泛素化和去泛素化的连续循环是 TGF-β信号转导所必需的。在这里，我们总结和讨论了 Smad 单泛素化和去泛素化的最新研究进展。
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