Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada.
1] Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver V5Z 1L3, Canada. [2] Department of Pathology & Laboratory Medicine, University of British Columbia, Vancouver V6T 2B5, Canada.
Nat Rev Cancer. 2014 Aug;14(8):517-34. doi: 10.1038/nrc3774. Epub 2014 Jul 10.
B cell lymphomas are cancers that arise from cells that depend on numerous highly orchestrated interactions with immune and stromal cells in the course of normal development. Despite the recent focus on dissecting the genetic aberrations within cancer cells, it has been increasingly recognized that tumour cells retain a range of dependence on interactions with the non-malignant cells and stromal elements that constitute the tumour microenvironment. A fundamental understanding of these interactions gives insight into the pathogenesis of most B cell lymphomas and, moreover, identifies novel therapeutic opportunities for targeting oncogenic pathways, both now and in the future.
B 细胞淋巴瘤是起源于正常发育过程中依赖于与免疫细胞和基质细胞发生大量高度协调相互作用的细胞的癌症。尽管最近的研究重点是解析癌细胞内的遗传异常，但越来越多的人认识到肿瘤细胞仍然依赖于与构成肿瘤微环境的非恶性细胞和基质成分之间的一系列相互作用。对这些相互作用的基本了解深入了解了大多数 B 细胞淋巴瘤的发病机制，并且，除此之外，还为靶向致癌途径提供了新的治疗机会，无论是现在还是将来。
