Peng Jing, Chen Chao, Chen Junjie, Su Xiang, Xi Chanjuan, Chen Hui
Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University , Beijing 100084, China.
Org Lett. 2014 Jul 18;16(14):3776-9. doi: 10.1021/ol501655g. Epub 2014 Jul 10.
Copper-catalyzed arylcarbocyclization reaction of alkynes was realized with diaryliodonium salts through C-C bond formation on an inert C(sp3)-H bond. This method provides an efficient cyclization of alkyl alkynes to generate carbocycles with good step-economy. Theoretical study revealed an interesting Cu-catalyzed concerted pathway of the C-C bond formation.
通过在惰性C(sp3)-H键上形成C-C键，实现了铜催化的炔烃与二芳基碘鎓盐的芳基碳环化反应。该方法提供了一种高效的烷基炔烃环化反应，以良好的步骤经济性生成碳环。理论研究揭示了一种有趣的铜催化C-C键形成协同途径。
