Turse Joshua E, Scoles Glen A, Deringer James R, Fry Lindsay M, Brown Wendy C
Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington, USA.
U.S. Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, Washington, USA.
Clin Vaccine Immunol. 2014 Sep;21(9):1369-75. doi: 10.1128/CVI.00246-14. Epub 2014 Jul 9.
Infection of cattle with Anaplasma marginale fails to prime sustained effector/memory T-cell responses, and high bacterial load may induce antigen-specific CD4 T exhaustion and deletion. We tested the hypothesis that clearance of persistent infection restores the exhausted T-cell response. We show that infection-induced T-cell exhaustion, characterized as loss of antigen-specific proliferation, and gamma interferon (IFN-γ) and tumor necrosis factor alpha (TNF-α) production are partially restored in cattle following clearance of persistent infection with tetracycline.
牛感染边缘无形体后无法引发持续的效应/记忆T细胞反应，高细菌载量可能会诱导抗原特异性CD4 T细胞耗竭和缺失。我们检验了这样一个假设，即清除持续性感染可恢复耗竭的T细胞反应。我们发现，在使用四环素清除牛的持续性感染后，感染诱导的T细胞耗竭（表现为抗原特异性增殖丧失以及γ干扰素（IFN-γ）和肿瘤坏死因子α（TNF-α）产生）得到了部分恢复。
