Nan Yue-Min, Wang Rong-Qi, Fu Na
Yue-Min Nan, Rong-Qi Wang, Na Fu, Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Shijiazhuang 050051, Hebei Province, China.
World J Gastroenterol. 2014 Jul 7;20(25):8055-60. doi: 10.3748/wjg.v20.i25.8055.
Alcoholic liver injury represents a progressive process with a range of consequences including hepatic steatosis, steatohepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. Targeting key molecular regulators involved in the development of alcoholic liver injury may be of great value in the prevention of liver injury. Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in modulation of hepatic lipid metabolism, oxidative stress, inflammatory response and fibrogenesis. As such, PPARα may be a potential therapeutic target for the treatment of alcoholic liver disease.
酒精性肝损伤是一个渐进的过程，会产生一系列后果，包括肝脂肪变性、脂肪性肝炎、肝纤维化、肝硬化和肝细胞癌。针对参与酒精性肝损伤发展的关键分子调节因子，可能对预防肝损伤具有重要价值。过氧化物酶体增殖物激活受体α（PPARα）在调节肝脏脂质代谢、氧化应激、炎症反应和纤维生成中起关键作用。因此，PPARα可能是治疗酒精性肝病的一个潜在治疗靶点。
