Lugao Renata dos Santos, Motta Marina Pamponet, de Azevedo Matheus Freitas Cardoso, de Lima Roque Gabriel Rezende, Abrantes Flávia de Azevedo, Abdala Edson, Carrilho Flair José, Mazo Daniel Ferraz de Campos
Renata dos Santos Lugao, Marina Pamponet Motta, Matheus Freitas Cardoso de Azevedo, Roque Gabriel Rezende de Lima, Flair José Carrilho, Daniel Ferraz de Campos Mazo, Hepatology Branch, Clinical Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo 05403-000, Brazil.
World J Gastroenterol. 2014 Jul 7;20(25):8304-8. doi: 10.3748/wjg.v20.i25.8304.
A variety of clinical manifestations are associated directly or indirectly with tuberculosis. Among them, haematological abnormalities can be found in both the pulmonary and extrapulmonary forms of the disease. We report a case of immune thrombocytopenic purpura (ITP) associated with intestinal tuberculosis in a liver transplant recipient. The initial management of thrombocytopenia, with steroids and intravenous immunoglobulin, was not successful, and the lack of tuberculosis symptoms hampered a proper diagnostic evaluation. After the diagnosis of intestinal tuberculosis and the initiation of specific treatment, a progressive increase in the platelet count was observed. The mechanism of ITP associated with tuberculosis has not yet been well elucidated, but this condition should be considered in cases of ITP that are unresponsive to steroids and intravenous immunoglobulin, especially in immunocompromised patients and those from endemic areas.
多种临床表现直接或间接与结核病相关。其中,血液学异常在肺结核和肺外结核中均可见。我们报告一例肝移植受者中与肠结核相关的免疫性血小板减少性紫癜(ITP)病例。最初使用类固醇和静脉注射免疫球蛋白治疗血小板减少症未成功,且缺乏结核症状妨碍了正确的诊断评估。在诊断为肠结核并开始特异性治疗后,观察到血小板计数逐渐增加。ITP与结核病相关的机制尚未完全阐明,但对于对类固醇和静脉注射免疫球蛋白无反应的ITP病例,尤其是免疫功能低下患者和来自流行地区的患者,应考虑这种情况。