Li Fenqiang, Wang Wenhui, Li Li, Su Dongjun, Chang Yaowen, Guo Gang, He Xuewen, Li Baohua
Department of Interventional Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China.
Exp Ther Med. 2014 Aug;8(2):539-544. doi: 10.3892/etm.2014.1784. Epub 2014 Jun 13.
This study aimed to examine the efficacy and safety of cryoablation, combined with zoledronic acid or alone, in the treatment of bone metastatic pain. A total of 84 patients were randomly divided into three groups: group A (cryoablation plus zoledronic acid), group B (cryoablation) and group C (zoledronic acid). In group A, the overall response [OR = complete response (CR) + partial response (PR)] was 85.7% (24/28), the CR was 35.7% (10/28) and the PR was 50.0% (14/28). In group B, the OR was 50.0% (14/28), the CR was 14.3% (4/28) and the PR was 35.7% (10/28). In group C, the OR was 67.9% (19/28), the CR was 21.4% (6/28) and the PR was 46.4% (13/28). The differences in OR, CR and PR among the three groups were statistically significant (P<0.05). The mean onset time of pain relief for the cryoablation combined with zoledronic acid treatment group was 1.96±2.26 days, for cryoablation treatment alone was 1.43±1.79 days and for zoledronic acid alone was 11.67±3.14 days; there were statistically significant differences among the three groups (P<0.05). The response duration was 146.68±1.89 days in group A, 71.60±2.94 days in group B and 112.99±1.37 days in group C; the differences among the three groups were statistically significant (P<0.01). In conclusion, cryoablation combined with zoledronic acid is an effective and safe therapeutic strategy for the treatment of bone metastatic pain.
本研究旨在探讨冷冻消融联合唑来膦酸或单独使用冷冻消融治疗骨转移性疼痛的疗效和安全性。总共84例患者被随机分为三组：A组（冷冻消融加唑来膦酸）、B组（冷冻消融）和C组（唑来膦酸）。A组的总缓解率[OR = 完全缓解（CR）+部分缓解（PR）]为85.7%（24/28），CR为35.7%（10/28），PR为50.0%（14/28）。B组的OR为50.0%（14/28），CR为14.3%（4/28），PR为35.7%（10/28）。C组的OR为67.9%（19/28），CR为21.4%（6/28），PR为46.4%（13/28）。三组之间的OR、CR和PR差异具有统计学意义（P<0.05）。冷冻消融联合唑来膦酸治疗组疼痛缓解的平均起效时间为1.96±2.26天，单纯冷冻消融治疗组为1.43±1.79天，单纯唑来膦酸治疗组为11.67±3.14天；三组之间存在统计学显著差异（P<0.05）。A组的缓解持续时间为146.68±1.89天，B组为71.60±2.94天，C组为112.99±1.37天；三组之间的差异具有统计学意义（P<0.01）。总之，冷冻消融联合唑来膦酸是治疗骨转移性疼痛的一种有效且安全的治疗策略。
