Nakano Yorika, Adachi Yasushi, Okamoto Hideki, Kiyama Yoshiaki, Koyama Takashi, Nakamura Shin-Ichi, Li Qing, Sakaida Noriko, Uemura Yoshiko, Ikehara Susumu
Department of Surgical Pathology, Kansai Medical University-Hirakata Hospital, Osaka 573-1191, Japan ; Division of Surgical Pathology, Toyooka Hospital, Hyogo 668-8501, Japan.
Division of Surgical Pathology, Toyooka Hospital, Hyogo 668-8501, Japan ; Department of Stem Cell Disorders, Kansai Medical University, Osaka 573-1010, Japan.
Oncol Lett. 2014 Aug;8(2):633-636. doi: 10.3892/ol.2014.2210. Epub 2014 Jun 2.
Other than that in the duodenum, adenocarcinoma in the small bowel is rare. The present study describes a case of adenocarcinoma with adenoma in the jejunum. A 70-year-old male was admitted to hospital due to dehydration induced by abdominal discomfort and difficulty with oral intake. Computed tomography revealed a tumor in the upper side of the jejunum, which was subsequently resected. The tumor contained adenocarcinoma and adenoma. The protein expression of p53 and Ki-67 was analyzed in the normal mucosa, adenoma and adenocarcinoma. The number of epithelial cells expressing p53 and Ki-67 was found to increase in the adenoma tissue compared with that in the normal mucosa. In the adenocarcinoma tissue, the number of cells expressing p53 and Ki-67 further increased, suggesting that an adenoma-adenocarcinoma sequence may occur in the small bowel, similar to that observed in the large bowel.
除十二指肠外，小肠腺癌较为罕见。本研究描述了一例空肠腺癌合并腺瘤的病例。一名70岁男性因腹部不适和经口摄入困难导致脱水入院。计算机断层扫描显示空肠上段有一个肿瘤，随后进行了切除。肿瘤包含腺癌和腺瘤。对正常黏膜、腺瘤和腺癌中的p53和Ki-67蛋白表达进行了分析。发现与正常黏膜相比，腺瘤组织中表达p53和Ki-67的上皮细胞数量增加。在腺癌组织中，表达p53和Ki-67的细胞数量进一步增加，提示小肠可能发生腺瘤-腺癌序列，类似于在大肠中观察到的情况。
