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Ras/Raf/MEK/ERK 通路在儿童急性淋巴细胞白血病中的激活及其治疗靶点。

Ras/Raf/MEK/ERK Pathway Activation in Childhood Acute Lymphoblastic Leukemia and Its Therapeutic Targeting.

机构信息

Newcastle Cancer Centre at the Northern Institute for Cancer Research, Newcastle University , Newcastle upon Tyne , UK.

出版信息

Front Oncol. 2014 Jun 24;4:160. doi: 10.3389/fonc.2014.00160. eCollection 2014.

DOI:10.3389/fonc.2014.00160
PMID:25009801
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4067595/
Abstract

Deregulation of the Ras/Raf/MEK/extracellular signal-regulated kinase pathway is a common event in childhood acute lymphoblastic leukemia and is caused by point mutation, gene deletion, and chromosomal translocation of a vast array of gene types, highlighting its importance in leukemia biology. Pathway activation can be therapeutically exploited and may guide new therapies needed for relapsed acute lymphoblastic leukemia and other high risk subgroups.

摘要

Ras/Raf/MEK/细胞外信号调节激酶通路的失调是儿童急性淋巴细胞白血病的常见事件，其原因是大量基因类型的点突变、基因缺失和染色体易位，这突显了它在白血病生物学中的重要性。通路激活可以被治疗性地利用，并可能指导复发急性淋巴细胞白血病和其他高危亚组所需的新疗法。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/ed1b8f590e89/fonc-04-00160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/f5bd356761e9/fonc-04-00160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/1abe9414ef22/fonc-04-00160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/ed1b8f590e89/fonc-04-00160-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/f5bd356761e9/fonc-04-00160-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/1abe9414ef22/fonc-04-00160-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5d0/4067595/ed1b8f590e89/fonc-04-00160-g003.jpg

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