Miyamoto M, Sasakawa S, Ozawa T, Kawaguchi H, Ohtsuka Y
Department of Research, Central Blood Center, Japanese Red Cross, Tokyo.
Biomaterials. 1989 May;10(4):251-7. doi: 10.1016/0142-9612(89)90101-4.
Latex particles induced platelet aggregation associated with the release of ATP from the platelets. The smaller the diameter of particles having the same surface structure, the greater numbers or greater total surface area of particles were required for both reactions. The higher hydrophobic and higher negatively charged particles, having a diameter of about 0.3 micron, induced platelet aggregation most easily. Hydrophilic particles without high negative surface potential activated platelets only a little. Particle-induced platelet aggregation is not only caused by colloidal electronic force and hydrophobic interaction between platelets and latex particles but also by factors concerning cell activation.
乳胶颗粒诱导的血小板聚集与血小板释放ATP有关。具有相同表面结构的颗粒直径越小，两种反应所需的颗粒数量越多或总表面积越大。直径约0.3微米、疏水性更高且带负电荷更多的颗粒最容易诱导血小板聚集。表面没有高负电位的亲水性颗粒仅轻微激活血小板。颗粒诱导的血小板聚集不仅由血小板与乳胶颗粒之间的胶体电子力和疏水相互作用引起，还由细胞活化相关因素引起。
