纵向炎症、认知衰退与阿尔茨海默病：一篇综述短文
Longitudinal inflammation, cognitive decline, and Alzheimer's disease: a mini-review.
作者信息
Bettcher B M, Kramer J H
机构信息
Neurology Department, Memory and Aging Center, University of California, San Francisco, San Francisco, California, USA.
出版信息
Clin Pharmacol Ther. 2014 Oct;96(4):464-9. doi: 10.1038/clpt.2014.147. Epub 2014 Jul 10.
Abstract
The role of inflammation in cognitive decline has generated considerable interest, although few longitudinal evaluations have been conducted. A review of the literature yields mixed findings but suggests that inflammatory dysregulation is evident and may be related to clinical outcomes. The directionality, magnitude, and progression of these associations remain unclear. Future studies employing multiple time points of inflammatory data along with Alzheimer's disease (AD) biomarkers are critical for explication of longitudinal inflammation in cognitive decline.
摘要
炎症在认知衰退中的作用已引发了相当大的关注，尽管进行的纵向评估很少。对文献的综述结果不一，但表明炎症失调很明显，且可能与临床结果相关。这些关联的方向性、程度和进展仍不明确。未来采用多个炎症数据时间点以及阿尔茨海默病（AD）生物标志物的研究对于阐明认知衰退中的纵向炎症至关重要。
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J Am Geriatr Soc. 2014 Apr;62(4):662-6. doi: 10.1111/jgs.12739. Epub 2014 Apr 2.
2
Effects of serum and plasma matrices on multiplex immunoassays.血清和血浆基质对多重免疫测定的影响。
Immunol Res. 2014 May;58(2-3):224-33. doi: 10.1007/s12026-014-8491-6.
3
C-reactive protein, APOE genotype and longitudinal cognitive change in an older population.C 反应蛋白、载脂蛋白 E 基因型与老年人群的纵向认知变化。
Age Ageing. 2014 Mar;43(2):289-92. doi: 10.1093/ageing/aft193. Epub 2013 Dec 3.
4
Inflammatory proteins in plasma are associated with severity of Alzheimer's disease.血浆中的炎症蛋白与阿尔茨海默病的严重程度有关。
PLoS One. 2013 Jun 10;8(6):e64971. doi: 10.1371/journal.pone.0064971. Print 2013.
5
How predictive of dementia are peripheral inflammatory markers in the elderly?老年人外周炎症标志物对痴呆症的预测性如何？
Neurodegener Dis Manag. 2012 Dec 1;2(6):609-622. doi: 10.2217/NMT.12.68.
6
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7
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J Gerontol A Biol Sci Med Sci. 2012 Sep;67(9):970-6. doi: 10.1093/gerona/glr261. Epub 2012 Feb 24.
8
Critical appraisal of four IL-6 immunoassays.四种 IL-6 免疫分析法的评价。
PLoS One. 2012;7(2):e30659. doi: 10.1371/journal.pone.0030659. Epub 2012 Feb 9.
9
C-reactive protein is related to memory and medial temporal brain volume in older adults.C-反应蛋白与老年人的记忆和内侧颞叶脑容量有关。
Brain Behav Immun. 2012 Jan;26(1):103-8. doi: 10.1016/j.bbi.2011.07.240. Epub 2011 Aug 6.
10
Systemic inflammation and delirium: important co-factors in the progression of dementia.全身性炎症和谵妄：痴呆进展的重要共同因素。
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